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Managing fatigue is critical to the future of aviation. Aircraft are increasingly able to operate longer sectors, and while our understanding of the relationship between human fatigue and performance continues to evolve, managing the balance between what is technically possible with what is humanly possible, is complex. In response to the need to manage fatigue-related risks, ICAO recently approved amendments to Annex 6 Part I, to include Fatigue Risk Management Systems (FRMS) Standards and Recommended Practices (SARPs).